Novel Associations for Coronary Artery Disease Derived from Genome Wide Association Studies Are Not Associated with Increased Carotid Intima-Media Thickness....

TitleNovel Associations for Coronary Artery Disease Derived from Genome Wide Association Studies Are Not Associated with Increased Carotid Intima-Media Thickness....
Publication TypeJournal Article
Year of Publication2011
AuthorsConde L, Bevan S., Sitzer M., Klopp N., Illig T., Thiery J., Seissler J., Baumert J., Raitakari O., Khnen M., Lyytikinen L.P, Laaksonen R, Viikari J., Lehtimki T., Koernig W., Halperin E, Markus H.S
Published inAtherosclerosis
Volume219
Issue2
Page(s)684-689
Other Numbers3257
Abstract

Full title: Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodelingBackgroundRecent genome-wide association studies (GWAS) have identified associations with myocardial infarction and coronary artery disease (CAD), but the mechanisms underlying these associations remain largely unclear. Carotid intima-media thickness (IMT) is a measure of early arterial remodeling and arteriosclerosis. Therefore, if CAD associated SNPs are also associated with carotid IMT; it suggests that they are acting via the early stages of the atherosclerotic process.MethodsIn three large community based independent populations (CAPS, KORA and Young Finns) of European ancestry in which common carotid IMT had been measured (total 4961 individuals), we determined whether SNPs that have been associated with CAD in GWAS studies are also associated with carotid IMT. Associations with plaque were not examined.ResultsWe identified 11 SNPs and one haplotype previously associated with CAD. None of these were associated with common carotid IMT.ConclusionsWe found no evidence that SNPs associated with CAD on GWAS are also associated with carotid IMT. This suggests these genetic associations are not acting via early vessel remodeling or early arteriosclerosis.

Bibliographic Notes

Atherosclerosis, Vol. 219, No. 2, pp. 684-689

Abbreviated Authors

L. Conde, S. Bevan, M. Sitzer, N. Klopp, T. Illig, J. Thiery, J. Seissler, J. Baumert, O. Raitakari, M. Khnen, L. P. Lyytikinen, R. Laaksonen, J. Viikari, T. Lehtimki, W. Koernig, E. Halperin, H. S. Markus

ICSI Research Group

Algorithms

ICSI Publication Type

Article in journal or magazine