Real-Time Control of Human Coagulation
Title | Real-Time Control of Human Coagulation |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Makin, J., & Narayanan S. |
Published in | IET Control Theory and Applications |
Volume | 6 |
Issue | 17 |
Page(s) | 2630-2643 |
Other Numbers | 3407 |
Abstract | In previous work, the authors showed that the dynamics of human blood clotting could be fruitfully modelled andsimulated as a hybrid system (HS), that is, one with interacting continuous and discrete parts. Here, the authors show that,although a complete analysis of the HS is (computationally) infeasible, analysis and control techniques can indeed be appliedto a large, critical subsystem a set of about 100 ordinary differential equations. The theory is outlined behind the controltechniques and then demonstrate in a series of simulations their application to control of pathological blood clotting, bothhypercoagulatory (factor-V Leiden) and hypocoagulatory (hæmophilia A). In particular, steering is simulated during a clottingevent of the crucial bloodprotein thrombin, via the controlled injection of (recombinant) factor VIII (for hæmophilia) or theanti-coagulant heparin (for FV Leiden). It remains to remedy the shortcomings of this control technique, and to extend it tothe remainder of the HS of the previous work; methods for these are proposed, and addressed in a subsequent article. |
URL | http://www.icsi.berkeley.edu/pubs/ai/humancoagulation12.pdf |
Bibliographic Notes | IET Control Theory and Applications, Vol. 6, Issue 17, pp. 2630-2643 |
Abbreviated Authors | J. Makin and S. Narayanan |
ICSI Research Group | AI |
ICSI Publication Type | Article in journal or magazine |