Publication Details
Title: A Hybrid-System Model of the Coagulation Cascade
Author: J. Makin and S. Narayanan
Group: AI
Date: March 2013
PDF: [Not available online]
Overview:
The process of human blood clotting involves a com- plex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenom- ena, where the former comprise the various chemical rate equations and the latter comprise both threshold- limited behaviors and binary states (presence/absence of a chemical). Whereas previous blood-clotting mod- els used only continuous dynamics and perforce ad- dressed only portions of the coagulation cascade, we capture both continuous and discrete aspects by mod- eling it as a hybrid dynamical system. The model was implemented as a hybrid Petri net, a graphical model- ing language that extends ordinary Petri nets to cover continuous quantities and continuous-time flows. The primary focus is simulation; specifically, we are inter- ested in (1) fidelity of simulation to the actual clotting process in terms of clotting factor concentrations and elapsed time; (2) simulating known clotting patholo- gies; and (3) providing fine-grained predictions which may be used to refine clinical understanding of blood clotting. Finally, we examine the sensitivity of a criti- cal purely-continuous subsystem to rate-constant per- turbation.
Bibliographic Information:
Proceedings of the 5th International Conference on Bioinformatics and Computational Biology (BICoB2013), Honolulu, Hawaii
Bibliographic Reference:
J. Makin and S. Narayanan. A Hybrid-System Model of the Coagulation Cascade. Proceedings of the 5th International Conference on Bioinformatics and Computational Biology (BICoB2013), Honolulu, Hawaii, March 2013
Author: J. Makin and S. Narayanan
Group: AI
Date: March 2013
PDF: [Not available online]
Overview:
The process of human blood clotting involves a com- plex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenom- ena, where the former comprise the various chemical rate equations and the latter comprise both threshold- limited behaviors and binary states (presence/absence of a chemical). Whereas previous blood-clotting mod- els used only continuous dynamics and perforce ad- dressed only portions of the coagulation cascade, we capture both continuous and discrete aspects by mod- eling it as a hybrid dynamical system. The model was implemented as a hybrid Petri net, a graphical model- ing language that extends ordinary Petri nets to cover continuous quantities and continuous-time flows. The primary focus is simulation; specifically, we are inter- ested in (1) fidelity of simulation to the actual clotting process in terms of clotting factor concentrations and elapsed time; (2) simulating known clotting patholo- gies; and (3) providing fine-grained predictions which may be used to refine clinical understanding of blood clotting. Finally, we examine the sensitivity of a criti- cal purely-continuous subsystem to rate-constant per- turbation.
Bibliographic Information:
Proceedings of the 5th International Conference on Bioinformatics and Computational Biology (BICoB2013), Honolulu, Hawaii
Bibliographic Reference:
J. Makin and S. Narayanan. A Hybrid-System Model of the Coagulation Cascade. Proceedings of the 5th International Conference on Bioinformatics and Computational Biology (BICoB2013), Honolulu, Hawaii, March 2013