TrioPhase - Genotyping Trios Using DNA Pools

TrioPhase - Genotyping Trios Using DNA Pools

Triophase is a software for genotyping DNA from mother-father-child trios, using two DNA pools per trio.
This method can be used for disease association studies that involve trios, in which case it reduces the genotyping cost by 33% without losing accuracy. The method is described in the paper

  • Kenneth B. Beckman, Kenneth A. Abel, Andreas Braun and Eran Halperin,
    Using DNA Pools for Genotyping Trios, Nucleic Acids Research, 2006; doi: 10.1093/nar/gkl700.
For a copy of the paper, please visit the
Nucleic Acids Research website.

The software is writen in C and it is compiled on a unix machine. To download the software, and for example input files, please click here.

This web-site is based upon work supported by the National Science Foundation under Grant No. 0513599. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.